Enhanced G2-M Arrest by Nuclear Factor-κB-Dependent p21waf1/cip1 Induction
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چکیده
منابع مشابه
Induction of apoptosis and G2/M arrest by 2-methoxyestradiol in human cervical cancer HeLaS3 cells.
BACKGROUND It has been demonstrated that 2-Methoxyestradiol (2-ME), one of the estrogen metabolites, induces apoptosis in many different tumor cell lines. In the present study, the effects of 2-ME on human cervical cancer HeLaS3 cells and on normal cervical epithelial cells were evaluated. MATERIALS AND METHODS Acridine orange staining, DNA fragmentation arrays and flow cytometry were used to...
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The glutamate transporter-1 [GLT-1 (excitatory amino acid transporter 2)] subtype of glutamate transporter ensures crisp excitatory signaling and limits excitotoxicity in the CNS. Astrocytic expression of GLT-1 is regulated during development, by neuronal activity, and in neurodegenerative diseases. Although neurons activate astrocytic expression of GLT-1, the mechanisms involved have not been ...
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Sunil K Manna €, , Julie S Bose , Vijay Gangan, Nune Raviprakash, Thota Navneetha, Pongali B Raghavendra, Banaganapalli Babajan, Chitta S Kumar, and Swatantra K Jain From the Laboratory of Immunology, Centre for DNA Fingerprinting & Diagnostics, Nampally, Hyderabad 500 001, India, Reliance Life Sciences Pvt. Ltd., Mumbai 400701, India; Department of Biochemistry, Sri Krishnadevaraya University,...
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OBJECTIVE The anti-neoplastic effects of decitabine, an inhibitor of DNA promoter methylation, are beneficial for the treatment of renal cell carcinoma (RCC); however, the mechanism of action of decitabine is unclear. We analyzed gene expression profiling and identified specific pathways altered by decitabine in RCC cells. METHODS Four human RCC cell lines (ACHN, Caki-1, Caki-1, and A498) wer...
متن کاملAnalysis for the Conflict between G2/M Phase Arrest in the Cell Cycle and Apoptosis Induction
When DNA is damaged by the irradiation or chemical agents in vitro, the damage signal activates the tumor suppressor protein p53 followed by the stimulation of the transcriptions of many related genes such as p21, 14-3-3, Bax, Bcl-2 and so fourth. These genes may determine the destination of the cell whether the cell cycle arrest or apoptosis induction. Thus, p53 is responsible for the conflict...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2005
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-05-0028